Integrin-Linked Kinase Regulates Integrin Signaling in Human Trabecular Meshwork Cells

摘要

This study shows that ILK can trans-dominantly control cooperative integrin signaling events used to regulate the organization of the actin cytoskeleton in differentiated HTM cells. Alterations in ILK activity are likely to affect how TM cells in vivo respond to ECM-mediated signals, thereby altering the functional properties of the TM, such as contractility.